Research Article
Dissolution Rate Enhancement of Ganciclovir by Solid Dispersions with Polyethylene Glycol 6000
Author: Rajib Kumar Rautray1, Bhagaban Biswal2, Ruchita Kumari Patra3, Soudamini Mallik3
Abstract: The aim of this study was to prepare and characterize solid dispersions of ganciclovir by solid dispersion techniques. Enhancing the solubility of the drug was also tried using different techniques like co-solvency, pH alteration, and micellization (cloud point technique). The phase solubility study of ganciclovir was conducted in the presence of various concentrations of PEG 6000. Negative values of Gibbs free energy value (∆G0tr) indicated spontaneity of ganciclovir solubilization. Solid dispersions of ganciclovir-PEG 6000 were prepared by physical mixing and melting techniques in w/w ratios of 1:1, 1:2, and 1:3 (drug: carrier). Characterization of the solid dispersions was carried out by differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). The dissolution profiles of solid dispersions were compared with those of the pure drug. The solid dispersion of ganciclovir with PEG 6000 prepared by melting technique at 1:3 ratio showed greater solubility when compared to other formulations. FTIR and DSC studies showed no significant interaction between ganciclovir and the hydrophilic carriers PEG 6000 used.
Keywords: Dissolution, solid dispersions, ganciclovir, PEG 6000, solubility.