Formulation and Evaluation of Fexofenadine HCl Fast Dissolving Tablets
Author (s): Malaya Kumar Dalai, Shakti Prasad Samantasinghara, Rashmiranjan Nayak, Meenakshi Behera,
Royal college of pharmacy and Health Sciences, Berhampur-2, Odisha.
Fexofenadine HCl is an antihistamine drug used in the treatment of hay fever and similar allergy symptoms. It does not readily pass through the blood-brain barrier and causes less drowsiness than first generation histamine-receptor antagonists. Rapid dispersible Tablets of Fexofenadine HCI immediate release tablets were designed to increase the dissolution rate by using super disintegrants. Different formulations of Fexofenadine HCl were prepared by direct compression method. These formulations were evaluated for hardness, thickness, friability, weight variation, disintegration time, and in vitro dissolution study. The USP paddle method was used to study the drug release from the formulations while keeping the temperature at 37 °C for 60 minutes. As super disintegrants, sodium starch glycolate, Ac-disol, and polyplasdone XL were utilized in concentrations of 3 percent, 6 percent, and 9 percent. As a result, only the ratio of super disintegrants was altered in each formulation, while all other excipients and the active ingredient (fexofenadine HCI) remained the same. According to USP, 0.001N HCI was utilized in this instance as the dissolution medium, and absorbances were measured using a UV spectrophotometer at 258 nm. By using FTIR studies revealed no interactions between the drug and excipients used. The best results are obtained using 6% of polyplasdone XL.
Keywords: Super disintegrants, wetting, test for dispersion.