Article 7


Adverse Drug Reactions of Commonly Used Antifungal Drugs – A Pharmacovigilance Study

Author (s): Amitder Nath Chatterjee, Barsha Giri, Debjit Kar

Kanak Manjari Institute of Pharmaceutical Sciences, Chhend Colony, Rourkela, Odisha, India.
Kanak Manjari Institute of Pharmaceutical Sciences, Chhend Colony, Rourkela, Odisha, India.
Jaiprakash Hospital and Research Centre Pvt. Ltd., Rourkela, Odisha, India.


Pharmacovigilance is mainly a study that involves safety of those drugs which are being marketed under the clinical use in practical conditions for larger communities. The aim of this pharmacovigilance study was to determine the adverse drug reactions (ADRs) of the antifungal drugs which are commonly being used at a tertiary health care hospital (Jaiprakash Hospital & Research Centre Pvt. Ltd.) at Rourkela. An observational, prospective type of examination of the ADRs has been conducted for a period of 1 month and 4 weeks (24th January, 2022 to 23rd March, 2022) in the OPD of the skin department of Jaiprakash Hospital & Research Centre Pvt. Ltd., Rourkela. During the study period, a total of 6 patients suffering from fungal infections have visited the OPD, and about 12 ADRs events were reported. Out of 12 ADRs which have been identified, a higher percentage of adverse drug reaction (ADRs) has been found in the males (66.67%) as compared to that in females (33.33%). Out of the 12 ADRs, higher number of ADRs has occurred in the age group of ≥ 43 years (83.33%) as compared to that of the age group of < 43 years (16.67%). On causality assessment, nearly 50% ADRs were considered as possible, about 41.67% ADRs were considered as probable, and about 16.67% ADRs were considered as definite. The present study is very much valuable in making the medicinal therapy rational and safer so as to improve the patients compliance.

Keywords: Pharmacovigilance, Antifungal, Adverse drug reactions, Naranjo scale, Fungal infection.

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