Potential of Herbal Drugs for Application against Alzheimer’s disease
Author (s):Pragyan Parimita Mansingh, Lopamudra Adhikari*, Shakti Ketan Prusty
Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India, 751003
Alzheimer’s disease (AD) is a neurological disease which progressively occurs in brain. Dementias are the most common form of Alzheimer’s disease. Symptomatically used drugs which are used in treating AD
include N-methyl D-aspartate (NMDA) receptor antagonist (memantine) and acetylcholinesterase inhibitors (AChEIs) (rivastigmine, galantamine, donepezil). Limited bioavailability of these drugs stresses continuity of search for novel therapeutics for this slow growing but complex disease. The memory related problems are treated by using the Herbal drugs, including Alzheimer’s. The therapeutic potential of herbal drugs demonstrated both clinical and preclinical studies for the prevention of AD. Herbal drugs against Alzheimer’s disease are possibly effective because of the multifaceted and pleiotropic action of the herbal drugs like neuroprotective, anti-inflammatory and antioxidants action. The current review aims to summarize the applications of herbs with anti-apoptotic and antioxidant properties in various invivo and invitro studies, different diagnostic tests for AD, mechanism of action associated with AD, stages and symptoms of AD, management of Alzheimer disease, therapeutic strategies of AD using herbal drugs,
different herbal compounds altering BBB, herbs with AChE action and there plant parts used, alternative approaches used against AD, different herbal nanoparticles used in AD as well as limitations of using herbal drugs.
Keywords: Alzheimer, herbal drugs, phytotherapy, neurodegenerative disease, brain,dementia.