Formulation and Evaluation of Oro-Dispersible Tablets of Paracetamol
Author (s): Girish Kumar Khora, Arun Kar, Radhakanta Mali, Rajat Kumar Purusottam
Abstract: This present investigation aimed at the formulation of Oro-Dispersible tablets (ODTs) of Paracetamol with different super disintegrants like PVP, SSG, and CMC using 4 %, 8 %, and 12 % concentration of tablet weight. Different formulations (F1 to F9) were prepared by direct compression method using rotary-die-compression machine keeping the hardness 3.5kg/cm2. Formulations containing crospovidone (cross-linked PVP) at 8 % concentration showed good results compared to tablets containing other superdisintegrants. This means crospovidone is better than cross-linked sodium CMC and SSG in this formulation of orodispersible tablets paracetamol. The Fourier transform infrared spectroscopy (FTIR) study showed no interaction between paracetamol and the used superdisintegrants, as there is no significant change in peak values for the characteristic functional groups in the drug paracetamol.
Keywords: Paracetamol, disintegration, superdisintegrants, wetting, orodispersible tablet.