Evaluate the anti-Anxiety, anti-convulsant and CNS depressant activities of ethanolic extracts of leaves of Pongamia pinnata
Author (s): Satyapriya Mahapatra,* Ritupriya Mohanty, Lorie Dehury, M. Manisha Kumari, Itishree Mohanty, Ishawar Mishra and Ghanshyam Panigrahi
The aim of the present study was to evaluate the anti-anxiety, anticonvulsant and CNS depressant activities of the ethanolic extract of leaves of Pongamia pinnata (EELPP). Phytochemicals of the EELPP were screened by standard methods and revealed that the extract contains alkaloid, glycoside, protein and amino acid, gum and mucilage, flavones and flavonoids, saponins, and steroids. The acute toxicity study revealed that the EELPP did not show any signs of toxicity or mortality even at the dose level of 2000 mg/kg body weight. Elevated plus maze, and light and dark model methods in rat were used for study the anti-anxiety activity of the extract; actophotometer method in rat was used for study the CNS depressant activity; and maximal electroshock method in rat was used for study the anti-convulsant activities. In the present study test group (EELPP 400 gm/kg treated) animals has showed significant anti-anxiety, anticonvulsant and CNS depressant activities as that of standard group (diazepam treated) animals. The results of the study indicates the ethanolic extract of leaves of Pongamiapinnatais having significant anti-anxiety, anti-convulsant and CNS depressant activities and hence scientifically justifies the use in the folklore remedies.
Keywords: Pongamia pinnata, anti-anxiety, anticonvulsant and CNS depressant