Article 7

Research Article

FORMULATION AND IN VITRO EVALUATION OF FLOATING MICROSPHERE OF PRAZOSIN HCl

Author (s): Lalita Sandey, Sandip Prasad Tiwari*


Abstract: The Impetus of the current learning was to acquire the floating microspheres of Prazosin hydrochloride is an advanced drug delivery system and to go through the drug to get the better of the reactions as orthostatic hypotension. The devising was compel by solvent evaporation method. In this study, the microspheres were assessed for elementary framework as appearance, dimension, lightness percentage, and drug entrapment order. The accumulating % drug free of upgraded expression succeeding 24 hours was 91.4%. Prototype installing survey give away the free design kept to Peppas-Korsmeyer. The out turn signify a good connection between the forecasting and fact-finding worth, supporting the logic of the version. FTIR exhibited that there is not drug and polymer contraction. It was concluded under accelerated studied formulations was optimized.


Keywords: Floating microspheres, Fourier transformed infrared radiation, HPMC, Prazosin hydrochloride, Solvent evaporation