SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT OF NEVIRAPINE SOLID DISPERSIONS USING SKIMMED MILK POWDER
Author (s): Medisetty Gayatri Devi1, Earle Radha Rani2, A. Lakshmi Usha2, P. Uma Devi1
Abstract: This research was aimed in enhancing solubility and rate of dissolution of nevirapine by employing solid dispersions. Saturation solubility studies and pH solubility profile were determined for nevirapine. Nevirapine solid dispersions with skimmed milk powder were prepared using techniques like solvent evaporation, physical mixing and microwave method. The obtained solid dispersions were tested for in vitro dissolution data and were characterized by FTIR analysis. Twelve different formulations of nevirapine with skimmed milk were prepared using solvent evaporation, physical mixing and microwave techniques. FTIR studies indicated absence of interactions between excipients and drug used. Nevirapine exhibited 16.2 % dissolution in 45 minutes, while dissolution rate of solid dispersion of nevirapine: skimmed milk powder (1:7) prepared by solvent evaporation showed 87.66 % drug release. Dissolution rate of nevirapine could be enhanced by preparation of solid dispersions with skimmed milk.
Keywords: Solid dispersions, skimmed milk, FTIR, pH solubility profile, solvent evaporation, microwave method.