Article 2

PHYTOCHEMICAL ESTIMATION AND ANTI- HEMORRHOIDAL ACTIVITY OF FICUS BENGHALENSIS LINN. PROP ROOT EXTRACT

Author (s): Reshma Chatterjee, Swapnil Patil, Alakh N Sahu*


Abstract: This present study was conducted to validate the traditional claim of the root extract of Ficus benghalensiswith black pepper for the treatment of hemorrhoids.The anti-hemorrhoidal property of Ficus benghalensis was evaluated by the help of the croton oil induced edema animal experimental model.Preliminary phytochemical screening of ethanolic extract of prop root had shown the presence of alkaloids, glycosides andtannins. Quantitative phytochemical estimation was also performed and total phenolic content was found to be 25.112 mg/g of Gallic acid equivalent (GAE).Hemorrhoids has been induced in the experimental wistar rats by the application of croton oil preparation (COP). The ethanolic prop root extract formulation with black pepper was found to reduce the severity score, the recto anal coefficient, Evans blue dye concentration and levels of TNF-a and IL-6. The extract formulation was found to be effective in the treatment of Hemorrhoids in experimental animals.


Keywords: Ficus benghalensis, anti-hemorrhoidal, hemorrhoids, croton oil