EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF ZIZIPHUS XYLOPYRUS STEM BARK EXTRACTS IN DIFFERENT EXPERIMENTAL ANIMAL MODELS
Author (s): U.S. Mishra*and P.N. Murthy
Abstract: The aim of the present study was to evaluate the analgesic and anti-inflammatory activities of chloroform and methanol extracts of stem barks of Ziziphus xylopyrus in different experimental animal models. Hot plate and tail immersion methods in mice were used for study the central analgesic activity; acetic acid writhing method in mice was used for study the peripheral analgesic activity; and carrageenan induced paw edema method in rat was used for study the anti-inflammatory activities. In the hot plate and tail immersion models, both chloroform and methanol extracts of stem barks of Z. xylopyrus at doses of 50, 100 and 200 mg/kg showed significantly increase the pain threshold. In the acetic acid writhing test the extracts of Z. xylopyrus showed significant inhibition of writhing. And in carrageenan induced paw edema method significant inhibition of paw edema by the stem bark extracts of Z. xylopyrus was found, which is comparable with the standard drug. Z. xylopyrusbark extracts showed dose-dependent action in all the experimental models. The results of the study indicates the plant Z. xylopyrus is having significant analgesic and anti-inflammatory activities and hence scientifically justifies the use in the folklore remedies.
Keywords: Ziziphus xylopyrus, anti-inflammatory, analgesic, writhing test