Formulation and Evaluation of Celecoxib In-Situ Ophthalmic Gel
Author (s): Asish Kumar Sahu, Ajit Kumar Acharya, Amiya Bhusan Mishra
Royal College of Pharmacy and Health Sciences, Berhampur-2, Odisha, INDIA
Conventional ophthalmic solution has many disadvantages like rapid drainage, so repeated dosing is required. In order to have prolonged effect in-situ gel may be a better option, as it increases the contact time of drug with corneal tissue. The main objective of the present work is formulation and evaluation of in situ ophthalmic gel for sustained drug action, decrease precorneal drug loss, increase corneal contact time. Celecoxib is a lipophilic drug having very low water solubility, so modified physical form of celecoxib prepared by kneading with β-CD (1:1) can be used for formulation of ophthalmic in-situ gel with 6 %w/v NaCl to have prolonged drug release.
Keywords: Celecoxib, BetaCyclodextrin, kneading, in situ ophthalmic gel, In vitro drug release