Techniques and Carriers used in Solubility Enhancement of Drugs: An Extensive Review
Author (s): Malaya Kumar Dalai, Ashutosh Sahu, Soumyaranjan Prusty, Ruchita Kumari Patra
Department of Pharmaceutics, Royal College of Pharmacy and Health Sciences, Berhampur,Odisha, INDIA
This review paper is written covering approaches techniques and hydrophilic carriers used in solubility hence dissolution rate enhancement of low soluble drugs (BSC Class 2). Solid dispersion is defined as the solid dispersion of one or more active pharmacological ingredients in a carrier, are useful approach for
improving the dissolution of low water-soluble drug and therefore increasing their bioavailability. Low water solubility is one of the key issues with numerous types of drugs, and various approaches have been developed to improve their solubility. Water Solubility is a problem for more than 60 percent of potent medicinal formulations. Solid dispersions have gained a lot of attention as a way to improve the dissolution rate and thus the bioavailability of a variety of hydrophobic drugs. Pharmaceutical polymers are at the heart of drug formulations in both traditional and novel drug delivery systems.
Keywords: solid dispersion,bioavailability,polymers,hydrophobic,solubility and dissolution