2021, Volume 2 Issue 3 – Article 5


Formulation and Evaluation of Orodispersible Tablets of Domperidone

Author (s): Saripilli rajeswari*, Diddi Aruna.

Department of Pharmaceutical Technology, Maharajah’s College of Pharmacy, Phool Baugh, Vizainagaram-535002, Andhra Pradesh, India.


The present study aimed to formulate orodispersible tablets of domperidone to increase its solubility and to enhance the patient compliance, provide a quick onset of action, as compared to marketed formulations. Dispersible tablets are easier to administer or swallow than capsule/conventional tablets for paediatrics, uncooperative, and those with conditions of motion sickness sudden episodes of allergic attacks or coughing. Domperidone is indicated for relief of nausea and vomiting. Orodispersible tablets were prepared by direct compression technique using βcyclodextrin (CD) with 3 different super disintegrants like as crospovidone, croscarmellose sodium and sodium starch glycolate in various concentration. The prepared powder mixtures were subjected to both pre and post compression evaluation parameters including; IR spectroscopy, tablet hardness, friability, wetting time, disintegration time and in vitro drug release. IR studies indicated that there was no interaction between the drug and excipients. Tablet hardness and friability indicated good mechanical strength of tablets. Wetting time decreased from 47.40±0.07 to 30.05±0.05 sec by increasing the super disintegrants concentration from 4 % to 8 % w/w of tablets. The formulation F2 which was prepared by using the 4% of crospovidone showed maximum drug release rate from 47.95±0.02 to 99.5±0.05% after 10 min. The formulation F2 with disintegration time 26.54 sec and dissolution rate 99.5±0.04 was selected as best formulation. Formulation F2 compared with conventional marketed formulation and F2 formulation was found to be superior.

Keywords: Domperidone,orodispersible tablets,crospovidone,croscarmellose sodium, sodium starch glycolate.

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