Effect of Polyethylene Glycol and PVP K-30 on the Solubility and Dissolution Rate Enhancement of Antihypertensive Drug Irbesartan
Author (s): Ranjit Prasad Swain
Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan
(Deemed to be University), Bhubaneswar, Odisha, India
Aim and objective: The study was aimed to improve the dissolution rate of poorly water-soluble drug irbesartan (IBS). Methods: The effects of PEGs (4000, 6000 and 8000) and PVP K-30 and methods of preparations in different ratios on dissolution behaviour of IBS were investigated. Selected formulations were characterized by FTIR, DSC. Results and discussion: FTIR and DSC showed the compatibility with the polymers. The significant change in melting pattern of the IBS observed in the DSC signified the transition to amorphous state. PEG 8000 based SD (1:5 w/w, SEM) showed significant enhancement of dissolution. Conclusion: It was concluded that SEM method and PEG 8000 as carrier were most suitable for the enhancement of the dissolution. This is an alternative approach for the enhancement of solubility and dissolution rate.
Keywords: Amorphous, polyethylene glycol, solubility, dissolution, PVP K-30.