2021, Volume 2 Issue 3 – Article 2



Author (s): Malaya Kumar Dalai*, P. N. Murthy, Ruchita Kumari Patra, Soudamini Mallick

P.G. Department of Pharmaceutics and P.G. Department of Pharmacology,
Royal College of Pharmacy and Health Sciences, Berhampur-760002, Odisha, India.


In vitro performance tests, such as dissolution tests, are performed for orally administered non-solution dosage forms for a variety of reasons. It is one of the quality control tests for oral solid dosage forms that are performed on a regular basis. Dissolution research began around 100 years ago as a field of physical chemistry and significant progress has been made since then. Aside from its significance in pharmaceutical analysis, it is also significant in pharmaceutical formulation technology and drug discovery. In this review paper, we will concentrate on various mathematical aspects of the dissolution process and the various dissolution apparatuses that are in use. We will go over some non-traditional dissolution testing methods. The main applications of the dissolution testing include biopharmaceutical characterization of the drug product, as a tool to ensure consistent product quality and to predict in vivo drug bioavailability. Dissolution testing was initially developed for solid orals, but its application has since expanded to a variety of novel dosage forms. The goal of this review is to represent all of the potential standardized test methods that are required to characterize the dissolution properties of a wide range of dosage forms, from traditional to novel delivery.

Keywords: Dissolution,solubility,dissolution medias,dissolution test apparatus, drug release testing and
dosage forms.

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