Development and Characterization of Gastroretentive Floating Tablets of Venlafaxine Hydrochloride by Thermoplastic Granulation Technique
Author (s): Ayalasomayajula Lakshmi Usha1*, Earle Radha Rani1, Akondi Vyasa Murthy1, Andhavarapu Venkata Srinivasa Ksheera Bhavani2.
Department of Pharmaceutics, Maharajah’s College of Pharmacy, Phool Baugh, Vizianagaram, AP, India -535002
Department of Pharmaceutical Technology, Sri Venkateswara College of Pharmacy, Etcherla, Srikakulam, AP, India
|Gastro retentive dosage forms (GRDFs) is the most feasible approach for achieving a prolonged and predictable drug delivery profile in the gastrointestinal tract. They control the gastric residence time of the drug. The aim of the present study is to formulate, develop and characterize gastroretentive floating tablet of an antidepressant drug Venlafaxine HCl. Venlafaxine HCl is a BCS class I drug having high solubility and permeability. The main objective of the study was to retain the drug in the gastric environment to prolong the drug release time. Twelve formulations were prepared by varying ratios of hydrophobic retardants such as carnauba wax, white paraffin wax, compritol ATO 888 and cetyl alcohol in combination with hydrophilic polymer HPMC K15M. The FTIR and DSC indicated compatibility between the drug and polymers used. The tablets were prepared by hot melt or Thermoplastic granulation method and were evaluated for various parameters such as tablet hardness, weight variation, friability, floating time and in vitro drug release profile. Formulation S6 with hydrophobic polymer cetyl alcohol and hydrophilic polymer HPMC K15M in the ratio of 1:3 was the optimized formulation. The optimized formulation showed sustained release of drug for a period of 12 h.|
Keywords: Gastro retentive, anti-depressant, melt granulation, buoyancy.