2021, Volume 2 Issue 2 – Article 4

Research

Formulation and Evaluation of Amoxicillin Mucoadhesive Tablets

Author (s): Dhruba Sankar Goswami1*, Prasanta Kumar Choudhuy2

1Gitanjali College of Pharmacy, Lohapur, Nalhati, Birbhum

2 Royal College of Pharmacy and Health Sciences, Berhampur, Ganjam, Odisha


Abstract:

Purpose of this research was to study mucoadhesive tablets of amoxicillin trihydrate using Moringa gum as mucoadhesive natural polymer. The conventional oral dosage form of this drug has low half-life and high dosing frequency. Plant gums and mucilages are being used due to their abundance in nature, safety and economy. So in The present investigation was an effort to study the suitability of gum obtained from Moringa oleifera as mucoadhesive polymer. The present study aims to reduce the dosing frequency by using single and combinations of synthetic and natural polymers for preparation of mucoadhesive tablets. Various approaches to combine synthetic (HPMC K4M, carbopol 934P and sodium alginate) and natural (moringa gum) polymers have been made to prepare total ten formulations. Further, different evaluation studies like friability, content uniformity, surface pH, wash-off and dissolution tests was done for all formulations. Results for in vitro drug release and wash-off studies suggest that the formulation (F1) containing Moringa gum has shown better mucoadhesive property. Other studies have shown satisfactory results in all ten formulations. Thus, the present investigation suggests that neem gum is suitable for preparation of mucoadhesive tablets.

Keywords: Neem gum, mucoadhesive, amoxicillin, H. pylori infection