Pressure Porosity Relationship: A Tool for Studying Physics of Tablet Compression
Author (s): Ch. Niranjan Patra
Professor, Roland Institute of Pharmaceutical Sciences, Berhampur, ODISHA.
Powder flowability and compressibility play a pivotal role in developing a tablet formulation. The parameters that are responsible to get the desired fluidity and compressibility of powders into tablets are 1. Particle size 2. Particle shape 3. Particle density 4. Nature of the powder (adhesive or cohesive). When the adhesive forces are more than the cohesive forces, the fluidity may be satisfactory, but not the compressibility. Similarly the cohesive forces are more than adhesive forces, the fluidity is poor. Thus these two pivotal parameters are necessary but behavior wise, they are diagonally opposite. The principal problem in processing of tablets, is a crucial issue in the industries. Thus the hidden or unseen or sometimes unexpected processing problems are in a complicated complex for the drugs. In the present editorial focus is given on use of different equations to study the pressure porosity relationships which in turn can be used in production of tablets with zero defects. The equations to study pressure porosity relationship such as kawakita, Heckel, Leuenberger can be used to study the physics of tablet compression for synthetic drug powders, herbal powders, herbal extracts, excipients, co-processed excipients, crystals, co-crystals etc. The data generated from such studies will be of good help for industries specially tablet manufacturers.
Keywords: Pressure porosity, Kawakita Equation, Heckel Equation, Leuenberger Analysis